Pseudo-Richter Transformation Following BTKi Interruption in CLL: A Systematic Review of Clinical, Biological, and Pathologic Features

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Key Points

Pseudo-Richter transformation presents critical clinical features in chronic lymphocytic leukemia (CLL), emphasizing the need for close monitoring.
Of the analyzed cases, 30% demonstrated notable pathologic changes post-BTKi interruption, highlighting potential implications for treatment strategies.
Systematic review of clinical and biological data reveals insightful correlations between bTK inhibitor treatment and disease progression in CLL patients.
Understanding these features may enable improved management and therapeutic approaches in CLL, although further validation is essential.

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Systematic review uncovers biological and pathologic features of pseudo-Richter transformation, suggesting further investigation is needed.

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Marco-Ayala et al. (2026) studied this question.

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