Identifying premenopausal patients with early-stage hormone receptor–positive breast cancer at minimal risk of distant recurrence by breast cancer index

Ruth O’Regan; Yue Ren; Yi Zhang; Gini F. Fleming; Prudence A. Francis; Olivia Pagani; Barbara Walley; Rita Pfister; Patrizia Dell’Orto; Giuseppe Viale; Sherene Loi; Marco Colleoni; Kai Treuner; Meredith M. Regan

doi:10.1016/j.breast.2026.104714

January 29, 2026The BreastOpen Access

Identifying premenopausal patients with early-stage hormone receptor–positive breast cancer at minimal risk of distant recurrence by breast cancer index

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Key Points

Patients estimated to have minimal-risk of distant recurrence within 10 years were identified using the BCI cutpoint—this is significant for treatment decisions.
The prognostic ability of the minimal-risk BCI cutpoint was confirmed in premenopausal patients with hormone-receptor-positive breast cancer.
BCI cutpoint classification can help in personalizing adjuvant endocrine therapy in patients treated for early-stage breast cancer conditions.
Findings suggest that careful patient selection may reduce unnecessary treatments and focus on effective therapy.

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Implication

Observational analysis identifies patients with minimal distant recurrence risk in premenopausal women, suggesting personalized therapy options.

Abstract

This study confirmed prognostic ability of the minimal-risk BCI cutpoint to classify patients estimated to have minimal-risk of distant recurrence within 10 years among premenopausal patients treated for hormone-receptor-positive node-negative breast cancer, providing relevant information for personalizing adjuvant endocrine therapy. SOFT: (clinicaltrials.gov NCT00066690) TEXT: (clinicaltrials.gov NCT00066703).

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Cite This Study

O’Regan et al. (2026) studied this question.

synapsesocial.com/papers/69a75dd1c6e9836116a2810e https://doi.org/10.1016/j.breast.2026.104714

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Identifying premenopausal patients with early-stage hormone receptor–positive breast cancer at minimal risk of distant recurrence by breast cancer index

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Identifying premenopausal patients with early-stage hormone receptor–positive breast cancer at minimal risk of distant recurrence by breast cancer index

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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