The circRNA0001707/miR-203a-3p/TLR4 regulatory axis drives macrophage polarization in enthesitis of newly diagnosed ankylosing spondylitis

Key Points

• Macrophage polarization is significantly driven by the circRNA0001707/miR-203a-3p/TLR4 axis in enthesitis.
• Key metrics include alterations in macrophage function pointing to a crucial regulatory pathway.
• Analysis utilizing gene expression profiling and macrophage functional assays provides robust evidence.
• Findings highlight the potential for targeted therapies focusing on this regulatory axis in ankylosing spondylitis.