Interferon levels and interferon-stimulated gene expression identify patient subsets with distinct clinical and immunological characteristics in systemic lupus erythematosus

Ridi Khatri; Amrutha Jose; Anjali M. Rajadhyaksha; Kalpana Mehta; Nilesh Nolkha; S H Kini; M Y Nadkar; Pooja Jaiswal; Pratiksha Pawar; Swapnal Pawaskar; Kavyasree Raj S.; Ajit Kumar Das; Jagadeesh Bayry; Kirti Rai; Harshada Konkar; Seema Korgaonkar; S. K. Patil; Prathamesh Warang; Aman Ullah Malik; Manisha Madkaikar; Vandana D. Pradhan

doi:10.3389/fimmu.2026.1757895

Key Points

Increased interferon levels are linked to distinct clinical traits and immune responses in systemic lupus erythematosus.
A significant correlation was found between IFNα levels and disease activity, measured by the SLEDAI score.
Assessment of IFN pathways at both protein and gene expression levels provides insights into SLE's clinical heterogeneity.
The identification of biomarkers may enable better disease monitoring and personalized treatment strategies for patients.

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Implication

Observational analysis reveals distinct immunological characteristics in subsets of systemic lupus erythematosus, suggesting potential biomarkers for monitoring disease activity.

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Khatri et al. (2026) studied this question.

synapsesocial.com/papers/69a75de3c6e9836116a282d2 https://doi.org/10.3389/fimmu.2026.1757895

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Interferon levels and interferon-stimulated gene expression identify patient subsets with distinct clinical and immunological characteristics in systemic lupus erythematosus

Key Points

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Implication

Abstract

Discussion

Cite This Study

Interferon levels and interferon-stimulated gene expression identify patient subsets with distinct clinical and immunological characteristics in systemic lupus erythematosus

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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