March 3, 2026Open Access

Identification of m1A/m6A/m5C/m7G-related genes and clusters associated with neuropathic pain

Key Points

Genes associated with RNA methylation, like Fto and Mettl3, may affect neuropathic pain.
Two RNA methylation-related DEG clusters were identified, highlighting their relevance to pain pathways.
MAPK and FoxO signaling pathways participate in the progression of neuropathic pain.
Research indicates significant roles of specific RNA modifications in pain mechanisms.

Abstract

Our findings reveal that genes associated with RNA methylation modifications, including Fto, Mettl3, Nsun2, and Ythdf3, may be involved in NP progression. Additionally, two RNA methylation-related DEG clusters were identified, and key pathways, such as the MAPK and FoxO signaling pathways, may participate in NP progression.

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Cite This Study

Tan et al. (Thu,) studied this question.

synapsesocial.com/papers/69a75de6c6e9836116a28313 https://doi.org/https://doi.org/10.3389/fneur.2026.1592545

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