Tumor-derived ITIH2 activates PI3K pathway via THBS1 ubiquitination and promotes tumor angiogenesis in hepatocellular carcinoma

Key Points

• Tumor-derived ITIH2 activates the PI3K/AKT pathway, promoting angiogenesis in hepatocellular carcinoma.
• The activation of this pathway is linked to the ubiquitination of THBS1, a key regulator of tumor growth.
• This analysis suggests that targeting ITIH2 or its pathway may offer new treatment avenues for liver cancer.
• Understanding how ITIH2 influences angiogenesis might pave the way for innovative cancer therapies.