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March 3, 2026The Egyptian Journal of Internal MedicineOpen Access

Correlation between serum Angiotensin II level and severity of COVID-19 disease

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Why the study?

SARS-CoV-2 entry via ACE2 causes upregulation of Angiotensin II, which correlates with severity of infection, prompting assessment of serum Ang II levels across COVID-19 disease severity.

Do serum Angiotensin II levels correlate with the severity of COVID-19 disease?

Population

80 COVID-19 patients and 80 healthy subjects

Comparison

COVID-19 patients across disease severities vs healthy controls

Design

Cross-sectional study

Authors

RERiem M. ElmessieryCairo UniversityHHHaitham Abdel Basset HashimCairo UniversityRMReem Hamdy A MohammedCairo University

Discussion

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Overview

May support Ang-II for COVID-19 risk stratification; hypothesis-generating and requires prospective validation before adoption.

Key Points

  • COVID-19 severity correlates with serum angiotensin II levels, indicating a potential marker for disease progression.
  • A significant correlation was noted, with higher serum levels linked to more severe COVID-19 cases.
  • Observational analysis assessed serum angiotensin II levels across COVID-19 patients with varying severity profiles.
  • This correlation could aid in identifying patients at higher risk for severe outcomes and guide clinical management.

Structured PICO

Do serum Angiotensin II levels correlate with the severity of COVID-19 disease?

P
Population
160 subjects: 80 patients with COVID-19 (divided into mild, moderate, severe, and critical groups according to WHO classification) and 80 healthy subjects.
I
Intervention
Measurement of serum Angiotensin II (Ang II) levels
C
Comparator
Healthy subjects and COVID-19 patients with varying disease severity (mild, moderate, severe, critical)
O
Outcome
Serum levels of Ang-II and its correlation with COVID-19 disease severitysurrogate

Serum Angiotensin II levels are significantly elevated in COVID-19 patients and strongly correlate with disease severity, suggesting its potential as a biomarker for risk stratification.

Cite This Study

Elmessiery et al. (2026) studied this question.

synapsesocial.com/papers/69a75e08c6e9836116a28630https://doi.org/10.1186/s43162-025-00581-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Serum Angiotensin II Level in Pediatric Patients with COVID-19 and its Correlation with the Disease Severity2024
  2. 2Serum ACE2 Level is Associated With Severe SARS-CoV-2 Infection: A Cross-Sectional Observational Study2022 · 11 citations
  3. 3Efficacy of Serum Angiotensin II Levels in Prognosis of Patients With Coronavirus Disease 20192021 · 32 citations
  4. 4C74-01 Renin Angiotensin Aldosterone System Components in Severe Covid-19: A Cross-sectional Study2026
  5. 5Soluble ACE2 and angiotensin II levels are modulated in hypertensive COVID-19 patients treated with different antihypertension drugs2022 · 12 citations