This case highlights the diverse and potentially misleading endoscopic manifestations of GI amyloidosis. NBI may aid in visualizing the distribution pattern and apparent depth of amyloid-related mucosal signals and serve as a supportive diagnostic tool; however, histological confirmation via Congo red staining remains the gold standard. The combination of image-enhanced endoscopy, targeted biopsies, and multidisciplinary evaluation may facilitate earlier recognition and more comprehensive management of patients with atypical gastric erythema.
Wang et al. (2026) studied this question.