SanHuang decoction may suppress breast cancer by regulating M1 macrophage polarization via NF-κB signaling pathway: in vitro and in vivo studies

Key Points

SanHuang decoction promotes M1 macrophage polarization, leading to increased cytokine expression and inflammatory response.
Findings indicate enhanced tumor microenvironment activity resulted in reduced breast cancer cell proliferation.
Observational analysis involved both in vitro and in vivo studies to assess the regulation of macrophage polarization.
Supporting evidence may enable new therapeutic strategies to target breast cancer progression with inflammation-related interventions.

Abstract

SHD could enhance the expression of M1/THP-1 cytokines, promote the inflammatory response in the tumor microenvironment, and thus inhibit the proliferation of BC and regulate its pathological process, likely through activating NF-κB signaling pathway.

SanHuang decoction may suppress breast cancer by regulating M1 macrophage polarization via NF-κB signaling pathway: in vitro and in vivo studies

Key Points

Abstract

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