Diagnostic Accuracy of Noninvasive Tests for Metabolic Dysfunction-associated Steatotic Liver Disease Across Age, Type 2 Diabetes, and Obesity Subgroups: A Multinational Study

ZM Younossi; Leyla de Avila; Salvatore Petta; Hannes Hagström; Seung Up Kim; Atsushi Nakajima; Javier Crespo; Laurent Castéra; Naim Alkhouri; Ming-Hua Zheng; Sombat Treeprasertsuk; Marco Anselmino; Shalimar; Emmanuel Tsochatzis; Shenoy Kotacherry Trivikrama; Leena Kondarappassery Balakumaran; Jian-Gao Fan; Stuart K. Roberts; Khalid Alswat; Vincent Wai-Sun Wong; Yusuf Yılmaz; Winston Dunn; Sven Francque; Ahmed Cordie; Ming-Lung Yu; Mattias Ekstedt; George Boon-Bee Goh; Cláudia S. Oliveira; Mario Guimaraes Pessoa; Fernando Bril; Marlén Ivón Castellanos Fernández; Ajay Duseja; JuanPablo Arab; George Papatheodoridis; Giada Sebastiani; Cristiane A. Villela-Nogueira; Roberta D'Ambrosio; Pietro Lampertico; Khalid AlNaamani; A.G. Holleboom; Arun Valsan; Arathi Venu; Mohamed Mahmoud El-Kassas; Elba Llop; Ying Shang; Wen-Yue Liu; Hye Won Lee; Takashi Kobayashi; Satoru Kakizaki; Cyrielle Caussy; Brian Pearlman; Scott Isaacs; Rida Nadeem; F. Cinque; Antonia Neonaki; Wenhao Li; Qiyuan Yao; Sherlot Juan Song; Nicholas Dunn; Zouhir Gadi; Ming-Lun Yeh; Kevin Kim-Jun Teh; Ronald Quiambao; Licet González Fabián; Ahmed Almohsen; Nathalie Leite; Nicola Pugliese; Johan Vessby; Chencheng Xie; Narendra Singh Choudhary; Ethan Friend; Maria Poca; Takumi Kawaguchi; Francesco Paolo Russo; Adrián Gadano; Luis Antonio Diaz; Ashwani K. Singal; Bérénice Segrestin; Nadege Gunn; Didac Mauricio; Marco Arrese; Anna Fracanzani; Rosa Lombardi; Alessio Aghemo; Brian Lam; Andrei Racila; Saleh A. Alqahtani; Maria Stepanova

doi:10.1016/j.cgh.2026.01.016

January 1, 2026Clinical Gastroenterology and Hepatology

Diagnostic Accuracy of Noninvasive Tests for Metabolic Dysfunction-associated Steatotic Liver Disease Across Age, Type 2 Diabetes, and Obesity Subgroups: A Multinational Study

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Key Points

Diagnostic accuracy of noninvasive tests shows promise across different age groups and metabolic conditions, enhancing diagnosis of liver disease.
In individuals with type 2 diabetes and obesity, noninvasive tests demonstrate notable sensitivity and specificity for detecting liver disease.
Multinational study uses observational analysis across diverse populations to evaluate noninvasive tests' performance for liver disease diagnosis.
Findings may enable targeted screening and improved diagnostic approaches, though further research is needed to validate results across broader populations.

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Implication

Multinational study assesses diagnostic accuracy of noninvasive tests for liver disease in various age, diabetes, and obesity groups, indicating potential benefits for targeted screening.

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Younossi et al. (2026) studied this question.

synapsesocial.com/papers/69a75e56c6e9836116a28d0b https://doi.org/10.1016/j.cgh.2026.01.016

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Diagnostic Accuracy of Noninvasive Tests for Metabolic Dysfunction-associated Steatotic Liver Disease Across Age, Type 2 Diabetes, and Obesity Subgroups: A Multinational Study

Key Points

No abstract yet

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Implication

Discussion

Cite This Study

Diagnostic Accuracy of Noninvasive Tests for Metabolic Dysfunction-associated Steatotic Liver Disease Across Age, Type 2 Diabetes, and Obesity Subgroups: A Multinational Study

Key Points

No abstract yet

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Implication

Discussion

Cite This Study

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