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March 3, 2026International Journal for Parasitology Drugs and Drug ResistanceOpen Access

A practical miracidial motility assay for assessing Fasciola hepatica sensitivity to compounds in vitro

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Authors

MZMengwei ZhengATAya C. TakiTSTanapan Sukee

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Overview

Automated assay evaluates motility inhibition of Fasciola hepatica miracidia, indicating drug efficacy against the parasite.

Key Points

  • Motility inhibition was observed in F. hepatica miracidia exposed to CLOS, TCBZ, and TCBZ-SO, with varying effectiveness.
  • CLOS showed the highest potency against isolates from New South Wales, Tasmania, and Victoria, while TCBZ and TCBZ-SO had isolate-specific sensitivity.
  • Automated miracidial motility assay developed using WMicroTracker ONE effectively quantifies sensitivity in vitro.
  • The findings highlight the assay's reproducibility and host-independent nature, enhancing drug efficacy assessment.

Cite This Study

Zheng et al. (2026) studied this question.

synapsesocial.com/papers/69a75e74c6e9836116a29118https://doi.org/10.1016/j.ijpddr.2026.100635
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