Robinin functionalized with ANP-loaded PLGA-PEG nanoparticles mitigate isoproterenol-induced stress via the AKT/GSK-3β signaling pathway

Key Points

• Mitigation of isoproterenol-induced stress is achieved through the AKT/GSK-3β signaling pathway.
• Robinin combined with ANP-loaded PLGA-PEG nanoparticles demonstrates significant effects in reducing stress.
• Analysis of nanoparticle functionalization indicates improved protective effects against isoproterenol stress.
• Findings suggest potential therapeutic uses for robenin in stress-related conditions, needing further validation.