Distinct and shared determinants of accelerated brain aging in temporal lobe epilepsy

Key Points

• Accelerated brain aging is significantly associated with specific neuroinflammation markers in temporal lobe epilepsy.
• Key biomarkers include oxidative stress levels, with higher levels correlating to cognitive decline.
• Analysis focuses on shared and distinct determinants of brain aging among individuals with temporal lobe epilepsy.
• Identifying these determinants may guide therapeutic approaches to mitigate cognitive decline.