Dose-response meta-analysis of plasma TMAO and stroke: validated linear risk threshold at 3.0 μmol/L

Key Points

• TMAO levels of 3.0 μmol/L correlate with increased stroke risk, indicating a significant threshold.
• The linear association reveals how higher TMAO concentrations relate to stroke likelihood in individuals.
• Meta-analysis across various studies supports the findings on TMAO and its impact on stroke incidence.
• Results suggest a need for monitoring plasma TMAO levels in clinical practice to mitigate stroke risk.