Mechanistic insights into drug loading effect on dissolution performance of Loratadine–Soluplus® amorphous solid dispersions

Key Points

• Dissolution performance improves with appropriate drug loading levels in amorphous solid dispersions.
• The study demonstrates a clear relationship between drug loading and dissolution, highlighting optimal loading at 30% for best performance.
• Analysis of mechanistic insights was conducted on loratadine and Soluplus® solid dispersions under controlled conditions.
• These findings may enable improved formulations in pharmaceutical applications, providing evidence for ideal loading parameters.