Ethyl ferulate suppresses choroidal neovascularization by accelerating Keap1 degradation through the inhibition of PSMD14-mediated deubiquitination

Key Points

• Choroidal neovascularization is significantly suppressed by ethyl ferulate treatment, indicating new therapeutic avenues.
• The mechanism involves accelerated degradation of Keap1, impacting cellular activity linked to disease progression.
• Utilization of inhibitor PSMD14 shows promise in enhancing the effects of ethyl ferulate on neovascularization.
• This study highlights the need for further exploration of ethyl ferulate as a potential treatment for eye diseases.