HER2-dependent paraptosis and ferroptosis induction by cannabidiol in breast cancer cells

Key Points

• Cannabidiol triggers ferroptosis and paraptosis in HER2-positive breast cancer cells, promoting cell death.
• The study shows a significant increase in cell death over a 48-hour period, with effects observed in various concentrations of cannabidiol.
• Analysis of breast cancer cell lines demonstrates the distinct pathways of paraptosis and ferroptosis activated by cannabidiol treatment.
• Findings imply possible therapeutic applications of cannabidiol in treating HER2-positive breast cancers, needing further clinical validation.