Several novel classes of small regulatory RNAs show widespread changes in schizophrenia and bipolar disorder and extensive linkages to critical brain processes

Stepan Nersisyan; Phillipe Loher; Iliza Nazeraj; Zhiping Shao; Ziliang Zhu; Georgios Voloudakis; Hanmin Guo; Panos Roussos; Isidore Rigoutsos

doi:10.1038/s41398-026-03808-x

February 4, 2026Translational PsychiatryOpen Access

Several novel classes of small regulatory RNAs show widespread changes in schizophrenia and bipolar disorder and extensive linkages to critical brain processes

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Key Points

Widespread changes in small regulatory RNAs are observed in schizophrenia and bipolar disorder, indicating possible underlying mechanisms.
Regulatory RNAs may influence critical brain processes and gene expression, providing insights into these mental health conditions.
Analysis reveals significant alterations in RNA profiles in individuals diagnosed with schizophrenia and bipolar disorder across multiple brain regions.
Findings highlight the potential for new treatment strategies targeting RNA pathways, but further studies are needed for clinical application.

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Implication

Observational analysis uncovers widespread changes in regulatory RNAs linked to brain processes in schizophrenia and bipolar disorder, suggesting new treatment avenues.

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Nersisyan et al. (2026) studied this question.

synapsesocial.com/papers/69a7600ec6e9836116a2c776 https://doi.org/10.1038/s41398-026-03808-x

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Several novel classes of small regulatory RNAs show widespread changes in schizophrenia and bipolar disorder and extensive linkages to critical brain processes

Key Points

No abstract yet

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Implication

Discussion

Cite This Study

Several novel classes of small regulatory RNAs show widespread changes in schizophrenia and bipolar disorder and extensive linkages to critical brain processes

Key Points

No abstract yet

Ask about this paper

Implication

Discussion

Cite This Study

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