Validation of a Multiplexed Quantitative PCR Assay for Obecabtagene Autoleucel CAR T cell Expansion and Persistence Monitoring

J. Aaron Grantham; Clayton Thomas; Jamie Nutt; Gregory Wood; Pierre Lao-Sirieix; Steven Kleiboeker

doi:10.1016/j.jtct.2025.12.276

February 1, 2026Transplantation and Cellular Therapy

Validation of a Multiplexed Quantitative PCR Assay for Obecabtagene Autoleucel CAR T cell Expansion and Persistence Monitoring

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Key Points

Expansion monitoring of CAR T cells is vital for assessing therapy effectiveness, as shown in this study.
Key evidence shows that the multiplexed quantitative PCR assay reliably tracks CAR T cell persistence over time, suggesting its diagnostic value.
Analysis utilized a multiplexed quantitative PCR assay to monitor CAR T cell expansion and persistence in cellular therapies; precision was emphasized.
These findings support the potential for improved patient monitoring using this assay, but further studies are needed for broader applications.

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Implication

Observational analysis validates CAR T cell expansion and persistence monitoring using a quantitative PCR assay, highlighting its utility in therapy assessment.

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Grantham et al. (2026) studied this question.

synapsesocial.com/papers/69a7601ac6e9836116a2c860 https://doi.org/10.1016/j.jtct.2025.12.276

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Validation of a Multiplexed Quantitative PCR Assay for Obecabtagene Autoleucel CAR T cell Expansion and Persistence Monitoring

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Validation of a Multiplexed Quantitative PCR Assay for Obecabtagene Autoleucel CAR T cell Expansion and Persistence Monitoring

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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