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March 3, 2026Environmental Research0 citationsOpen Access

Associations of prenatal exposure to organophosphate pesticides with eczema and allergic rhinoconjunctivitis in 4-year-old children: The Japan Environment and Children's Study

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MMMegasari MarselaHIHiroyoshi IwataYBYu Ait Bamai

Key Points

  • Eczema risk increases in children aged 4 exposed to organophosphate pesticides before birth, particularly with lower IgE levels.
  • Children with lower IgE levels display a notable association between prenatal DMP and DMTP exposure and eczema incidence.
  • Analysis of prenatal pesticide exposure reveals no links to allergic rhinoconjunctivitis or changing IgE levels in the population studied.
  • These findings may indicate a need for further investigation into the health impacts of pesticide exposure on children's respiratory and skin health.

Abstract

Prenatal DMP and DMTP were associated with an increased risk of eczema in children aged 4, with this association confined to children with DMTP and lower IgE levels, while no associations were found with AR or IgE levels.

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Cite This Study

Marsela et al. (2026) studied this question.

synapsesocial.com/papers/69a76034c6e9836116a2cb64https://doi.org/10.1016/j.envres.2026.123839
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Also Consider

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  1. 1Early Environmental Exposures and Intracellular Th1/Th2 Cytokine Profiles in 24-Month-Old Children Living in an Agricultural Area2006 · 93 citations
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  3. 3Measurement of pesticides and other toxicants in amniotic fluid as a potential biomarker of prenatal exposure: a validation study.2003 · 258 citations
  4. 4High immunoglobulin E level is associated with increased readmission in children with bronchopneumonia2019 · 9 citations
  5. 5Natural history of “intrinsic” atopic dermatitis2001 · 125 citations