Real-World Cost of Cytokine Release Syndrome (CRS) and Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS) Following CAR T-cell Therapy, in US Adults with B-ALL

Eric Roeland; David Bertwistle; Prashant Joshi; Dilip Patel; David Huggar

doi:10.1016/j.jtct.2025.12.164

February 1, 2026Transplantation and Cellular Therapy

Real-World Cost of Cytokine Release Syndrome (CRS) and Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS) Following CAR T-cell Therapy, in US Adults with B-ALL

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Key Points

Cytokine release syndrome and neurotoxicity lead to significant healthcare costs, impacting patient management.
The analysis identified average treatment costs exceeding $100,000 for incidents of CRS and ICANS post CAR T-cell therapy.
Observational analysis assessed healthcare expenditures in relation to treatment outcomes and adverse events.
Impacts and financial burdens from these syndromes highlight the need for improved cost management strategies.

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Implication

Observational analysis reveals high healthcare costs related to CRS and ICANS in adults with B-ALL, suggesting financial impact of CAR T-cell therapy.

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Cite This Study

Roeland et al. (2026) studied this question.

synapsesocial.com/papers/69a7605dc6e9836116a2d0a7 https://doi.org/10.1016/j.jtct.2025.12.164

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Real-World Cost of Cytokine Release Syndrome (CRS) and Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS) Following CAR T-cell Therapy, in US Adults with B-ALL

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Real-World Cost of Cytokine Release Syndrome (CRS) and Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS) Following CAR T-cell Therapy, in US Adults with B-ALL

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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