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Observational analysis reveals lipid profile changes and defective phagocytosis in human retinal pigment epithelium, indicating potential mechanisms driving retinal degeneration.
Our work has established the first human iRPE models to study the effects of peroxisome dysfunction in the RPE. Impaired peroxisome activity resulted in significant lipid profile changes and defective phagocytosis in iRPE. Dysregulated POS metabolism in the RPE is a potential mechanism driving retinal degeneration in patients with PBDs. Fully understanding the role of peroxisomes in the RPE will facilitate the development of novel therapies for degenerative retinal disorders.
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Mouzaaber et al. (2026) studied this question.
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