Calpain Mediated Proteolysis of Junctophilin-1 Produces an Aggregation Prone C-Terminal Fragment in Skeletal Muscle

Key Points

• Aggregation of the C-terminal fragment from Junctophilin-1 increases in skeletal muscle, leading to potential cellular dysfunction.
• Key evidence indicates calpain activity leads to significant proteolysis of Junctophilin-1, thereby affecting muscle fiber integrity.
• Analysis focused on calpain-mediated processes revealed that this proteolysis contributes to protein aggregation in muscle cells.
• Understanding this mechanism supports further exploration of therapeutic strategies targeting muscle degradation.