Prospective Evaluation of Medication Variability in Tacrolimus Levels and Social Determinants of Health As Predictors of Gvhd in Children Undergoing Hematopoietic Stem Cell Transplant

Key Points

• GVHD risk is significantly associated with variability in tacrolimus levels and social determinants of health.
• In this cohort, elevated tacrolimus variability was linked to a 37% increased risk of developing GVHD.
• Observational analysis focused on social determinants alongside medication management in pediatric HSCT.
• Findings suggest that better management of tacrolimus and understanding social factors may improve outcomes.