Establishment of accurate estimation equations for area under the concentration curves using simultaneous limited sampling for extended-release tacrolimus and mycophenolic acid in kidney transplant recipients

Key Points

The equation C0-C1-C3-C6 estimates both TAC-ER and MPA AUC accurately, showing strong correlation with R² over 0.95.
Validation demonstrates the efficacy of the LSS technique for estimating pharmacokinetics in a clinical setting.
This analysis supports the use of simultaneous limited sampling for effective medication monitoring in renal transplant patients.
Implementation of these estimation equations could reduce healthcare costs and improve patient management for kidney transplant recipients.

Abstract

Four equations (C0-C1-C6, C0-C1-C2-C6, C0-C1-C3-C6, C0-C1-C4-C6) showed strong correlations with the actual AUC (R² > 0.95), with the validation identifying C0-C1-C3-C6 as the most reliable for both TAC-ER and MPA. This study demonstrated that LSS using C0-C1-C3-C6 reliably and accurately estimated both the actual TAC-ER AUC0-24 and MPA AUC0-12 simultaneously in kidney transplant recipients. These equations can be feasibly implemented in outpatient clinical settings to reduce time and cost.

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