RNA-sequencing reveals immediate early genes upregulation in early stage of hippocampus in mouse model of Alzheimer’s disease

Key Points

• Immediate early genes are significantly upregulated in the hippocampus during early Alzheimer’s disease stages.
• Key observations include the expression changes of immediate early genes linked to Alzheimer's pathology.
• RNA-sequencing technique identifies these gene changes in a mouse model of Alzheimer's disease, supporting mechanistic understanding.
• Insights from this research may lay groundwork for potential therapeutic targets; mouse model limits findings.