Impact of Bispecific Antibody Exposure on CAR T-cell Manufacturing and Toxicity: A Retrospective Analysis

Key Points

• Manufacturing efficiency of CAR T-cells is affected by exposure to bispecific antibodies, which may increase toxicity.
• In the analysis, a notable rise in adverse events correlated with bispecific antibody exposure was found.
• Retrospective analysis of clinical data reveals insights into the relationship between exposure and CAR T-cell outcomes.
• Findings underscore the need for caution when using bispecific antibodies during CAR T-cell therapy preparations.