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Understanding the Nature of the Alloreactive T-cell Dysfunction Induced By Post-Transplantation Cyclophosphamide | Synapse
March 3, 2026
Understanding the Nature of the Alloreactive T-cell Dysfunction Induced By Post-Transplantation Cyclophosphamide
NS
Natália Schneider
National Institutes of Health
RF
Rochelle Fletcher
National Institutes of Health
SK
Saurabh Kumar
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Key Points
Dysfunction of alloreactive T-cells has been observed following cyclophosphamide treatment.
Key metrics highlight significant differences in T-cell activation levels after transplantation.
Observational analysis investigates T-cell immune responses and the effects of cyclophosphamide.
These findings call for further exploration of immunosuppression techniques in transplantation.
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Schneider et al. (Sun,) studied this question.
synapsesocial.com/papers/69a760cec6e9836116a2de7c
https://doi.org/https://doi.org/10.1016/j.jtct.2025.12.330