Advancing CAR-T therapy in prostate cancer: overcoming the tumor microenvironment and enhancing efficacy

Key Points

• Innovations in CAR-T therapy aim to enhance its efficacy against prostate cancer, overcoming tumor microenvironment challenges.
• Recent advances include improved CAR design and novel combination strategies that show promise in treatment effectiveness.
• This review highlights CAR-T targets and various engineering strategies that can lead to better treatment outcomes in prostate cancer.
• Addressing the tumor microenvironment remains crucial for achieving durable responses in advanced prostate cancer cases.