Pyridine-linked 1,3,4-oxadiazoles decorated with secondary amines as α-amylase inhibitors: Synthesis, crystal structure, enzyme kinetics and computational studies

Key Points

• The synthesized compounds exhibit effective inhibition of alpha-amylase activity.
• Inhibition was quantified, showing over 75% inhibition at optimal concentrations.
• Analysis involved enzyme kinetics and detailed crystal structure studies to validate findings.
• Computational studies indicate favorable binding interactions, highlighting potential drug design pathways.