Induction of apoptosis and downregulation of ERa in DMBA-induced mammary gland tumors in Sprague–Dawley ratsby synthetic 3,5-disubstituted isoxazole derivatives

Key Points

• Induction of apoptosis occurs in mammary gland tumors induced by DMBA, leading to tumor shrinkage.
• Significant downregulation of ERa (estrogen receptor alpha) is observed in treated tumors following isoxazole derivative administration.
• Synthetic 3,5-disubstituted isoxazole derivatives are assessed for their impact on tumor characteristics in a rat model.
• This work highlights potential therapeutic benefits of isoxazole derivatives, emphasizing the need for further studies in clinical settings.