Induction of apoptosis and downregulation of ERa in DMBA-induced mammary gland tumors in Sprague–Dawley ratsby synthetic 3,5-disubstituted isoxazole derivatives | Synapse
March 3, 2026
Induction of apoptosis and downregulation of ERa in DMBA-induced mammary gland tumors in Sprague–Dawley ratsby synthetic 3,5-disubstituted isoxazole derivatives
Key Points
Induction of apoptosis occurs in mammary gland tumors induced by DMBA, leading to tumor shrinkage.
Significant downregulation of ERa (estrogen receptor alpha) is observed in treated tumors following isoxazole derivative administration.
Synthetic 3,5-disubstituted isoxazole derivatives are assessed for their impact on tumor characteristics in a rat model.
This work highlights potential therapeutic benefits of isoxazole derivatives, emphasizing the need for further studies in clinical settings.