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February 14, 2026Journal of Biotechnology

Development of a serum-free producer cell line generation process for scalable and efficient rAAV production for gene therapy applications

José Miguel Escandell Mafalda Dias MJ Gonçalves Daniel A. M. Pais Andreia Conceição Amit K. Mathur Barak Balva Saurabh Sen Bruno Figueroa Karen A. Vincent Patrícia Gomes-Alves

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Key Points

Efficient production process leads to enhanced rAAV yield for gene therapy applications, ensuring scalability.
The development of a novel serum-free method showcases significant improvements in overall production efficiency and stability.
Analysis used a systematic approach to generate stable producer cell lines suitable for large-scale rAAV production.
This work highlights the potential of serum-free methods in reducing production costs while enhancing product quality for gene therapies.

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Implication

Observational analysis develops a serum-free process for scalable rAAV production in gene therapy applications, suggesting improved efficiency.

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Cite This Study

Escandell et al. (2026) studied this question.

synapsesocial.com/papers/69a76165c6e9836116a2f471 https://doi.org/10.1016/j.jbiotec.2026.02.006

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