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March 3, 2026Biochemical and Biophysical Research Communications0 citations

Protection mechanism of epalrestat on glutamate-induced retinal excitotoxicity model based on network pharmacology

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JHJiping HuangJinan UniversitySZShaomei ZhaoFirst Affiliated Hospital of Jinan UniversityJHJining HuangJinan University

Key Points

  • Epalrestat reduces glutamate-induced retinal excitotoxicity, offering neuroprotection.
  • The analysis indicates a significant reduction in cell death and inflammation markers.
  • Analysis using network pharmacology identified multiple protective pathways for epalrestat.
  • The findings suggest potential therapeutic applications but require further validation in clinical settings.
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Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/69a7618ec6e9836116a2f922https://doi.org/10.1016/j.bbrc.2026.153490
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