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February 1, 2026Clinical Gastroenterology and HepatologyOpen Access

Upadacitinib Maintenance Therapy in Pediatric Ulcerative Colitis: 52-week Multicenter Study from the Porto Group of ESPGHAN

Anat Yerushalmy-Feler Elizabeth A. Spencer Marla C. Dubinsky David L. Suskind Katarína Mitrová Ondřej Hradský Máire A. Conrad Judith R. Kelsen Malgorzata Sladek Pai-Jui Yeh Christos Tzivinikos Paul Henderson Magdalena Wlazlo Lukas Hackl Dror S. Shouval Natalia Mouratidou Matteo Bramuzzo Darja Urlep Christine Olbjørn Giulia Mancuso Anna-Maria Schneider Gemma Pujol-Muncunill Dotan Yogev Ben Kang Marco Gasparetto Christine Rungø Claudio Romano Massimo Martinelli Kaija-Leena Kolho Iva Hojsak Lorenzo Norsa Firas Rinawi Naire Sansotta Ramit Magen‐Rimon Maya Granot Luca Scarallo Eunice Trindade Marta Velasco Rodríguez-Belvís Dan Turner Shlomi COHEN

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Key Points

Maintenance therapy with upadacitinib significantly improved clinical outcomes in pediatric ulcerative colitis patients.
After 52 weeks, 70% of participants achieved remission, indicating a strong treatment response.
Multicenter study design ensured diverse patient representation, enhancing the reliability of the findings.
The results suggest the need for further evaluation of long-term benefits and safety in this young demographic.

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Implication

Multicenter study reveals effective maintenance therapy in pediatric ulcerative colitis, suggesting potential benefits for management.

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Cite This Study

Yerushalmy-Feler et al. (2026) studied this question.

synapsesocial.com/papers/69a761a2c6e9836116a2faae https://doi.org/10.1016/j.cgh.2026.02.012

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Management of paediatric ulcerative colitis, part 1: Ambulatory care—An updated evidence‐based consensus guideline from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition and the European Crohn's and Colitis OrganisationClinical Guideline · 2025 · 40 citations
2Effectiveness and Safety of Ustekinumab in Pediatric Ulcerative Colitis: A Multi-center Retrospective Study from the Pediatric IBD Porto Group of ESPGHAN2024 · 23 citations
3Tofacitinib in Pediatric Ulcerative Colitis: A Retrospective Multicenter Experience2024 · 28 citations
4Upadacitinib Induction and Maintenance Therapy for Crohn’s DiseaseOriginal Research · 2023 · 484 citations
5Upadacitinib Was Efficacious and Well-tolerated Over 30 Months in Patients With Crohn’s Disease in the CELEST Extension StudyRCT · 2021 · 64 citations

More related papers

Upadacitinib for Induction of Remission in Paediatric Crohn's Disease: An International Multicentre Retrospective Study2025
Real-World Experience with Upadacitinib for Pediatric Acute Severe Ulcerative Colitis: An International Multicenter Retrospective Study from the Pediatric IBD Porto Group of ESPGHAN2025
Single-center Experience With Upadacitinib for Adolescents With Refractory Inflammatory Bowel Disease2023

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