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February 1, 2026Hematology/Oncology Clinics of North America

Classic Hodgkin Lymphoma in the Older Adult

Carrie Sha Sarah C. Rutherford

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Key Points

Classic Hodgkin lymphoma presents unique challenges in older adults, impacting treatment approaches.
Survival rates demonstrate significant variability according to treatment type and patient characteristics.
Assessment of biomarkers helps to refine risk stratification among this population, enhancing personalized care.
Findings suggest a need for improved treatment protocols to address age-related factors in older adults.

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Implication

Observational analysis reveals treatment outcomes in older adults with classic Hodgkin lymphoma, highlighting critical survival factors.

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Cite This Study

Sha et al. (2026) studied this question.

synapsesocial.com/papers/69a761dbc6e9836116a2feee https://doi.org/10.1016/j.hoc.2025.12.009

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1The efficacy and tolerability of adriamycin, bleomycin, vinblastine, dacarbazine and <scp>S</scp>tanford <scp>V</scp> in older <scp>H</scp>odgkin lymphoma patients: a comprehensive analysis from the <scp>N</scp>orth <scp>A</scp>merican intergroup trial <scp>E</scp>2496Original Research · 2013 · 142 citations
2Randomized Phase III Trial of ABVD Versus Stanford V With or Without Radiation Therapy in Locally Extensive and Advanced-Stage Hodgkin Lymphoma: An Intergroup Study Coordinated by the Eastern Cooperative Oncology Group (E2496)RCT · 2012 · 308 citations
3BEACOPP, a new dose-escalated and accelerated regimen, is at least as effective as COPP/ABVD in patients with advanced-stage Hodgkin's lymphoma: interim report from a trial of the German Hodgkin's Lymphoma Study Group.Original Research · 1998 · 193 citations
4Standard and Increased-Dose BEACOPP Chemotherapy Compared with COPP-ABVD for Advanced Hodgkin's DiseaseOriginal Research · 2003 · 838 citations
5Escalated-Dose BEACOPP in the Treatment of Patients With Advanced-Stage Hodgkin's Lymphoma: 10 Years of Follow-Up of the GHSG HD9 StudyCohort Study · 2009 · 500 citations

More related papers

Evaluation of treatment outcome in 175 patients with Hodgkin lymphoma aged 60 years or over: the SHIELD study2012
Brentuximab Vedotin with Chemotherapy for Stage III or IV Hodgkin’s Lymphoma2017
Older patients (aged ≥60 years) with previously untreated advanced-stage classical Hodgkin lymphoma: a detailed analysis from the phase III ECHELON-1 study.2022

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