Prenatal exposure to antiseizure medications and risk of autism spectrum disorder in offspring: an integrated pharmacovigilance and two-sample mendelian randomization study

Key Points

• Autism spectrum disorder risk increases with prenatal exposure to antiseizure medications, suggesting a link.
• The study identifies specific pharmacovigilance data to support the connection between exposure and outcome.
• Mendelian randomization offers robust analysis of genetic data to assess causal relationships in this context.
• Findings highlight the need for cautious prescribing of antiseizure medications during pregnancy due to potential risks.