Schisandrol A induces cardiac developmental toxicity in zebrafish (Danio rerio) via disruption of calcium homeostasis, oxidative stress, and apoptosis

Key Points

• Cardiac developmental toxicity is evident following exposure to Schisandrol A, showing significant harm to heart formation.
• In zebrafish models, disruption of calcium homeostasis, oxidative stress, and apoptosis are key factors identified.
• Assessment using zebrafish as a model organism reveals how Schisandrol A disrupts normal heart development processes.
• These findings highlight potential risks associated with Schisandrol A, emphasizing the need for caution in its use.