Neutrophil extracellular traps induce airway epithelial-mesenchymal transition in a neutrophil-dominant asthmatic murine model through Hedgehog/Gli1 pathway

Key Points

• Epithelial-mesenchymal transition is induced by neutrophil extracellular traps in the airway.
• Mice with a neutrophil-dominant asthma model show significant pathway activation.
• Analysis focused on the Hedgehog/Gli1 signaling pathway, instrumental in cell transition processes.
• These findings suggest the need for further exploration into targeting this pathway for asthma treatment.