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March 3, 2026Journal of Pharmaceutical and Biomedical AnalysisOpen Access

Development and validation of an UPLC–MS/MS method for simultaneous determination of meropenem and its open-ring metabolite in human serum and cerebrospinal fluid with application to clinical samples

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Authors

XCXiangLong ChenJXJinhui XuCWChengliang Wang

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Overview

Analysis reveals simultaneous measurement of meropenem and its metabolite in human samples, indicating improved monitoring for CNS infections.

Key Points

  • Meropenem and its open-ring metabolite were effectively quantified in human serum and cerebrospinal fluid samples.
  • The method showed a sensitivity limit of 416.2 m/z for the open-ring metabolite, representing the first detection in human CSF.
  • Chromatographic separation was achieved using an Agela Venusil MP C18 column with acetonitrile as a solvent.
  • This validation provides a reliable tool for monitoring meropenem during treatment of CNS infections.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69a7658abadf0bb9e87d9796https://doi.org/10.1016/j.jpba.2026.117389
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