The potential role of COX-2/PGs signaling pathway in epileptogenesis and associated neuroinflammation: collusions or serendipity

Key Points

• Epileptogenesis is associated with the activation of the COX-2/PGs signaling pathway, highlighting a crucial role in neuronal inflammation.
• Key evidence indicates that increased COX-2 expression correlates with heightened neuroinflammation in epileptic models.
• Observational analysis of signaling pathways reveals a connection between neuroinflammation and COX-2/PGs in epilepsy.
• This study supports further exploration of COX-2/PGs as therapeutic targets for preventing epilepsy-related inflammation.