Background: Infection by avian pathogenic Escherichia coli (APEC) in broiler chickens leads to serious health complications, including systemic inflammation, oxidative stress, and impaired immune response. Aim: This study aimed to evaluate the effect of mangosteen peel extract nanocapsule (MPE-NC) on the hematological profiles and total bacteria in APEC-infected broilers. Methods: A total of 200 DOC broiler chickens were randomly allocated to four treatments with five replicates, including T1 (negative control group), fed a basal diet without APEC infection; T2 (positive control group), fed a basal diet with APEC infection; T3: a basal diet supplemented with 0.5% MPE-NC and APEC infection; and T4: a basal diet supplemented with 1.0% MPE-NC and APEC infection. The observed parameters were the hematological blood profile and total bacterial count. Results: APEC infection significantly (p < 0.05) impaired the physiological status of broiler chickens by reducing hematological parameters and had a significant effect on total bacteria (p < 0.05). The hematological parameters were significantly improved and the intestinal bacterial count was reduced in broiler chickens supplemented with MPE-NC compared to control treatment. Conclusion: MPE-NC treatment provided optimal improvement for several tested measurements. These results indicate that MPE-NC could be used as a natural phytobiotic agent to improve physiological health and reduce the risk of bacterial infection.
Kusmayadi et al. (Thu,) studied this question.