Chitosan and dialdehyde starch as macromolecular platforms for sulfa azo dye/selenium nanocomposites: Synthesis, molecular modelling, and dual DNA gyrase–DHFR inhibition

Key Points

• Dual inhibition of DNA gyrase and dihydrofolate reductase was demonstrated, indicating a promising therapeutic strategy.
• The synthesis of sulfa azo dye/selenium nanocomposites utilized chitosan and dialdehyde starch as macromolecular platforms.
• Molecular modeling provided insights into the interaction mechanisms of the nanocomposites with target enzymes.
• Using these macromolecular platforms may enhance drug delivery and efficacy in therapeutic applications.