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March 3, 2026Biochimie0 citations

Controlled CRISPR/Cas12a activation via DNAzyme-mediated splitting of chimeric substrate for lead detection

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PZPeiying ZhangMSMeng ShenLDLihua Ding

Key Points

  • Lead detection increased by 3.5 times with CRISPR/Cas12a activation and DNAzyme technique.
  • Efficient use of a chimeric substrate permits precise control in lead detection assays.
  • Investigative approach employs DNAzyme splitting to activate CRISPR technology for improved outcomes.
  • Highlights the potential for utilizing CRISPR/Cas12a in environmental monitoring and safety applications.
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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69a76610badf0bb9e87db828https://doi.org/10.1016/j.biochi.2026.02.001
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Synergistic Incorporation of Two ssDNA Activators Enhances the Trans-Cleavage of CRISPR/Cas12a2023 · 71 citations
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  5. 5Sensitivity of a classic DNAzyme for Pb 2+ modulated by cations, anions and buffers2020 · 24 citations