Efficacy and safety of minocycline in patients with acute ischaemic stroke (EMPHASIS): a multicentre, double-blind, randomised controlled trial

Key Points

• Efficacy of minocycline was found to be significant in reducing complications associated with acute ischaemic stroke, enhancing recovery.
• The trial enrolled multiple centers and was conducted as a double-blind, randomised controlled study over a defined period.
• Safety assessments revealed that adverse effects were similar between minocycline and placebo groups, indicating a favorable safety profile.
• This work may enable clinicians to explore minocycline as a therapeutic agent for patients experiencing acute ischaemic stroke.