Dose regimen optimization of cephalothin for surgical prophylaxis against Staphylococcus aureus and coagulase negative staphylococci in dogs by pharmacokinetic/pharmacodynamic modeling

Key Points

• Cephalothin dosage optimization significantly reduces the risk of infections from staphylococcus aureus and coagulase negative staphylococci.
• Modeling shows that effective prophylaxis is achieved with the right pharmacokinetic and pharmacodynamic parameters.
• Assessment through pharmacokinetic/pharmacodynamic modeling enhances understanding of drug behavior in canine patients.
• Results imply more effective surgical prophylaxis against bacterial infections in veterinary practices may be achievable.