Prediction of vancomycin exposure in patients with central nervous system infections using physiologically based pharmacokinetic modeling

Key Points

• Accurate prediction of vancomycin exposure enhances treatment outcomes.
• Physiologically based pharmacokinetic modeling shows strong potential for personalized medicine in this context.
• This study utilizes a simulation approach with relevant pharmacokinetic parameters to construct models.
• Improved dosing regimens could lead to better management of central nervous system infections.