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February 6, 2026Molecular & Cellular Toxicology

RNA-binding protein TARDBP enhances NPTX1 stability to induce neuronal injury and diabetic cognitive impairment

GuiTing Liu XiaoXuan Qi SiOu Li Xinyan Li TingYuan Han LingJia Cui Hanxun Yue Feng Liu Ying Lin

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Key Points

Neuronal injury is associated with increased TARDBP levels, leading to cognitive impairment.
Changes in NPTX1 stability affect neuronal health and cognitive function in diabetes.
The molecular pathway involves the interaction between TARDBP and NPTX1, impacting neuronal integrity.
Understanding this pathway may suggest therapeutic targets for diabetic cognitive dysfunction.

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Implication

Observational analysis reveals TARDBP increases NPTX1 stability, causing neuronal injury and cognitive impairment in diabetes.

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Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69a76744badf0bb9e87e03b5 https://doi.org/10.1007/s13273-026-00608-8

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