Dental plaque metabolites induce polymorphonuclear leukocyte death accompanying peptidyl arginine deiminase 4 and citrullinated protein release: Potential contribution to rheumatoid arthritis pathogenesis

Key Points

• Dental plaque metabolites significantly induce death in polymorphonuclear leukocytes, suggesting a connection to inflammation.
• Key outcomes include the release of citrullinated proteins and activation of peptidyl arginine deiminase 4.
• Assessment of dental plaque metabolites highlights their involvement in rheumatoid arthritis pathogenesis.
• Further research is needed to clarify the pathway and implications for treatment strategies.