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February 5, 2026Clinical Rheumatology

Development of a non-genetic risk prediction model for allopurinol-induced severe cutaneous adverse drug reactions: a multicenter retrospective observational study

Suppachai Lawanaskol Tassaneeyakul Wichittra Chonlaphat Sukasem Niwat Saksit Parinya Konyoung Nontaya Nakkam Warayuwadee Amornpinyo Ticha Rerkpattanapipat Kelly Barta P. Rerknimitr Thawinee Jantararoungtong Duangkamon Poolpun Kittiphan Chalom Apichat Tantraworasin J. Patumanond W. Louthrenoo Patapong Towiwat

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Key Points

Severe cutaneous adverse drug reactions were effectively predicted using a new model.
The model highlights three key risk factors in a diverse multicenter dataset.
This retrospective observational study assesses historical patient data across multiple clinics.
Findings underscore the need for better screening tools to manage drug reactions.

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Implication

Retrospective observational study develops a risk prediction model for allopurinol-induced skin reactions, suggesting improved patient safety.

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Cite This Study

Lawanaskol et al. (2026) studied this question.

synapsesocial.com/papers/69a76765badf0bb9e87e0b99 https://doi.org/10.1007/s10067-026-07967-6

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

12020 American College of Rheumatology Guideline for the Management of GoutSystematic Review · 2020 · 814 citations
2HLA-B*58:01 for Allopurinol-Induced Cutaneous Adverse Drug Reactions: Implication for Clinical Interpretation in ThailandOriginal Research · 2016 · 86 citations
3Strong association between HLA-B*5801 and allopurinol-induced Stevens–Johnson syndrome and toxic epidermal necrolysis in a Thai populationCross-Sectional Study · 2009 · 407 citations
4HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinolOriginal Research · 2005 · 1,294 citations
5Diagnostic utility of HLA‐B*5801 screening in severe allopurinol hypersensitivity syndrome: an updated systematic review and meta‐analysisMeta-Analysis · 2017 · 57 citations

Risk factors of allopurinol-induced severe cutaneous adverse reactions in a Thai population2017
Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations2014
Starting dose is a risk factor for allopurinol hypersensitivity syndrome: A proposed safe starting dose of allopurinol2012
Incidence and prevalence of connective tissue disease (CTD)-associated interstitial lung disease in the United StatesClinical Rheumatology · 2026
Single-cell eQTL Mendelian randomization reveals the monocyte-associated PRKCB–CTSL axis as a candidate regulatory pathway and potential therapeutic target in rheumatoid arthritisClinical Rheumatology · 2026

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