Multifunctional hydrogel integrating phototherapy and tumor microenvironment remodeling combined with immunotherapy for synergistic treatment of HCC

Key Points

• Enhanced efficacy in treating HCC was observed with the integration of phototherapy and immunotherapy via a hydrogel.
• The combination notably improved tumor responses, leading to a significant reduction in tumor growth and enhanced immune activity.
• Innovative hydrogel technology allows for sustained immunotherapy and phototherapy delivery in the tumor microenvironment.
• This approach may enable novel treatment paradigms for liver cancer, highlighting the potential for broader applications in cancer therapy.